Infant deaths associated with human parechovirus infection in Wisconsin.

The molecular diagnosis of parechovirus infection: has the time come?

Human parechoviruses (HPeVs) as a distinct entity are largely unknown to clinicians and often forgotten by diagnostic virologists. In this issue of Clinical Infectious Diseases, Sedmak et al [1] report the association of HPeV with sudden unexplained infant deaths. Over a period of 17 years, the Milwaukee County Medical Examiner’s Office and the City of Milwaukee Health Department Laboratory inv...

A Child with Acute Encephalopathy Associated with Quadruple Viral Infection

UNLABELLED Pediatric acute encephalopathy (AE) was sometimes attributed to virus infection. However, viral infection does not always result in AE. The risk factors for developing infantile AE upon virus infection remain to be determined. Here, we report an infant with AE co-infected with human herpesvirus-6 (HHV-6) and three picornaviruses, including coxsackievirus A6 (CVA6), Enterovirus D68 (E...

[Human parechovirus-3 infection in a neonate with fever and suspected sepsis].

The human parechovirus (HPeV) are viruses of the recently described Picornaviridae family and are causing several infections in young children. The pathology associated with these viruses is beginning to emerge. The HPeV type 3, has been described particularly in association with sepsis-like febrile syndromes, meningitis and encephalitis in very young infants and neonates. We report the case of...

Can We Distinguish between Human Parechovirus Type 3 and Enteroviruses Infection in Neonates and Young Infants Based on their Clinical and Laboratory Findings?

Nosocomial Outbreak of Parechovirus 3 Infection among Newborns, Austria, 2014

In 2014, sepsis-like illness affected 9 full-term newborns in 1 hospital in Austria. Although results of initial microbiological testing were negative, electron microscopy identified picornavirus. Archived serum samples and feces obtained after discharge were positive by PCR for human parechovirus 3. This infection should be included in differential diagnoses of sepsis-like illness in newborns.